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81601594, 51690153, 21720102005), the National Key R&D Program of China (grant numbers 2017YFA0205400, 2017YFA0701301), and the Natural Science Foundation of Jiangsu Province (BK20202002)

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If these immune checkpoint receptors become upregulated, proliferating T cells can become unresponsive to stimulation, entering a state called T cell exhaustion, eventually succumbing to apoptosis (Figure 2) [83,84,85], in which checkpoint ligands like PD-1 interacts with PD-L1 expressed by human granulomas [86] leads to reduced T cell cytotoxicity, proliferation, and activation [87]

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