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Effect of the volatile oil of Nigella sativa on the arterial blood pressure and heart rate of the Guinea-pig

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published in Hormone Research, oral AOD-9604 given to obese Zucker rats for 19 days reduced body weight gain by more than 50% compared to controls, with no adverse effect on insulin sensitivity confirmed by euglycemic clamp testing

In contrast, oxidized forms of sulfur-containing amino acids (e.g., methionine sulfoxide, cystine), as well as of arginine, increased (Figure 4A)