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It inhibits class-I histone deacetylases, remodels chromatin and gene expression, activates an anti-inflammatory receptor, and competes with acetyl-CoA in anabolic reactions 264,379,380,381,382

MPS saturation, often observed even after a single high-dose nanoparticle administration, can temporarily impair macrophage-mediated clearance of subsequent particles or pathogens, though this effect is not always sustained [274]

When the intake of free sugars exceeds 10% of the total energy consumption, the incidence of dental caries is significantly higher (WHO, 2015)

Urinary tract obstruction

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Blocking TDO and IDO1 to improve the efficacy of cancer immunotherapy would be complementary