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Chronic exposure to cigarette smoke promotes iron accumulation and excessive ROS, fueling Fenton reactions and the formation of peroxynitrite (ONOO )

DDCI: dopa-decarboxylase inhibitor

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In melanoma (B16-F10 and A375) cells, its ability to decrease MMP-2 and MMP-9 protein expression and suppress the Wnt/ -catenin pathway suggesting a therapeutic strategy for highly metastatic tumors [466]