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More importantly, there are several aspects of irAEs that we do not understand and which are the source of several controversies in the field

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Indeed, recent work has likewise implicated cell cycle arrest, induced either by p53 activation or CDK4/6 inhibition, in sensitizing fibrosarcoma cells to GPX4 inhibition 51

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Glutathione and other antioxidants neutralize free radicals, lower systemic inflammation, and promote cellular repair critical for managing chronic conditions long-term