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Further, AcHz is either hydrolysed to Hz by amidases or can undergo another step of acetylation, leading to the formation of DiAcHz

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There is evidence that these reactions occur within atherosclerotic plaques and they present the most accepted putative mechanism of a direct participation of GGT in the pathophysiology of atherosclerosis leading to promotion of atherosclerotic process, plaque instability and coronary ischemic events (89)

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is supported by a Federal Government Belgium grant, long-term structural Methusalem funding by the Flemish Government, a Concerted Research Activities Belgium grant, grants from the FWO, Foundation against Cancer and ERC Advanced Research Grant