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In the context of obesity, AKT1 associated signaling alterations is known to promote adipocyte hypertrophy, lipid storage, and macrophage recruitment, but its involvement in non-obesity-related disorders such as lipedema has not been previously characterized [60,61,62]

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In addition, diabetic acromegalic patients present with more pronounced left ventricular hypertrophy compared to nondiabetic patients [106]

In addition, increasing the dietary fiber content or a calorie-restricted diet, and exercise training can also modulate energy balance, thereby promoting health and reducing the incidence of disease [429, 598]

The European Cancer Anaemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients

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