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Weight loss during this phase is typically modest, around 3 to 5 pounds, as your body adjusts to the medication

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Mitochondrial dysfunction and ROS production can damage the ER, triggering further stress responses ( 3.3 Lysosomal: iron release and autophagic regulation Lysosomes are key organelles for degradation, recycling, and metabolic regulation (77)

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In total, 200 ng trypsin (Promega, Sequencing-Grade Trypsin, V5111) was added to each sample and shaken overnight at 37 C

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