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Since 2012, regulatory agencies such as the FDA and EMA have officially recognized the pivotal role of MS approaches in predicting the risk of DDIs during new drug development and have issued corresponding regulatory guidance [136, 137]

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Furthermore, the stringent regulatory requirements for new multi-target therapies make the approval process more suitable for single-target drugs, necessitating adjustments that could hinder progress and increase costs

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297 , R12831292 (2009)

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