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Understanding why metabolic inhibitors have failed in clinical trials is instructive: early glycolysis inhibitors showed toxicity to glucose-dependent normal tissues including the brain and immune system

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Nat Rev Mol Cell Biol 22:266282 Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC (2005) Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV