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We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]

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Later, Jins group showed that the endogenous H 2 S/CSE pathway was suppressed in MCT-induced PH rats, and exogenous H 2 S reduced pulmonary artery pressure, reversed pulmonary vascular structural remolding by suppressing phosphorylation of NF-B p65 and IB MCT-treated rats (Feng et al., 2017)

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