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These kinases possess a modulatory capacity for cellular activities and might phosphorylate transcription regulators, or proteins overseeing gene modulation

Statistical significance was tested by One-way ANOVA followed by Tukey post hoc test

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doi:10.1136/bmjgast-2019-000302 106Tofacitinib (Xeljanz): new measures to minimise risk of venous thromboembolism and of serious and fatal infections

Pharmacodynamic Vs Pharmacokinetic Assays for DOAC Measurement Two general types of coagulation assays can be used to assess an anticoagulants presence or activity functional, pharmacodynamic (PD) assays that measure the dynamics of clot formation as its endpoint (Figure 1), and quantitative or pharmacokinetic (PK) assays that measure drug concentration9